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St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 25: Investigations about God Must Be Rational and Humble

If someone should reply, what then? Are the giving of names and the choice of apostles, and the Lord’s activity, and the arrangement of created things something empty and aimless?1 We would answer: Certainly not! On the contrary, all things have clearly been made by God harmonious and beautiful with great wisdom and care, both the ancient things and whatever his Word has made in this last epoch. One must, however, not connect these things with the number thirty, but with an existing system.2 Nor should one make an inquiry into God by means of numbers and syllables and letters. For that would be a weak system because of the multitude and variety [of numbers, syllables, letters], and because at the present day every kind of system that has been similarly devised by someone can draw from these numbers testimonies contrary to the truth, since they [numbers] can be adapted to many things. On the contrary, the numbers themselves and all created things must be harmonized with the existing system of truth. For a rule does not come from numbers, but numbers from a rule; neither does God [come] from created things, but created things come from God. For all things are from the one and same God.

Here is the idea of simplicity: numbers cannot contain God, but God contains them. “For a rule does not come from numbers, but numbers from a rule; neither does God [come] from created things, but created things come from God. For all things are from the one and same God.”
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 25: Investigations about God Must Be Rational and Humble

For a rule does not come from numbers, but numbers from a rule; neither does God [come] from created things, but created things come from God. For all things are from the one and same God.

As Irenaeus refutes that we should not put numbers on God, Irenaeus says this.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 25: Investigations about God Must Be Rational and Humble

For a rule does not come from numbers, but numbers from a rule; neither does God [come] from created things, but created things come from God. For all things are from the one and same God.

Creator-creature relationship
We are being continually formed and conformed to his image, continually growing into the perfection. Haer. 4.39.2-3.
Economy
The aim of God’s economy is the perfection of humanity, and that is conforming humanity unto his likeness. Diffusing his simpleness into us his goal.
Simpleness--multiplicity in unity. Abundance and richness in unity and harmony.
“God, thus, determining all things before hand for the perfection of the human being, and towards the realization and manifestation of his economies, that goodness may be displayed and righteousness accomplished, and that the Church may be ‘conformed to the image of his Son’ [Rom. 8:29], and that, finally, the human being may be brought to such maturity as to see and comprehend God. (haer. 4.37.7)
John Behr takes it this way: “Human disobedience, apostasy, and death are, as we have already seen, inscribed into the very unfolding of the economy; death results from human action, but it is nevertheless a result that is subsumed and transformed within the larger arc of the economy, as it brings the creature made from mud to share in the very life, glory, and power of the Uncreated, so demonstrating the goodness and righteousness of God. Worked out in and through the life of each individual human being, if they should respond with faith and thankfulness, the conclusion is also corporate, for in this way the Church is conformed to Christ as each human being is brought to see God.” (Irenaeus of Lyons, 194)
The church is where the nature of God is to be reflected, and here, in his simplicity.
By describing how God did not create human beings perfect, Behr says that bring humanity into perfection is God’s aim in his economy. He says, “By definition the created cannot be uncreated, but more importantly the omnipotence of God is in fact demonstrated, for Irenaeus, by the way that the created is brought in time to share in the uncreated life of God, a change in the ‘fashion’ of its existence or the mode of its life, which requires preparation and training, for this is what the whole economy, including disobedience and death, effects.” (195)
Behr continues, “There if, moreover, no end to this process; never becoming uncreated, the perfection of human beings lies, instead, in their continual submission to the creative activity of God, through which he is brought to share in the glory and power of the Uncreated. (Haer. 4.38.3)” [cf. 4.11.2; here Behr recognizes “the whole tenor of Irenaeus’ thought on this point is strikingly similar to that of Gregory of Nyssa, e.g. Perf. GNO 8.1, 214; cf. J. Danielou, L’Etre et le temps chez Gregoire de Nysse (Leiden: Brill, 1970), 114.
Here is an amazing quote of Irenaeus: “By this order and such rhythms and such a movement the created and fashioned human becomes in the image and likeness of the uncreated God: the Father planning everything well and commanding, the Son executing and performing, and the Spirit nourishing and increasing, and the human being making progress day by day and ascending towards perfection, that is, approaching the Uncreated One. For the Uncreated is perfect, and this is God. Now, it was first necessary for the human being to be created; and having been created, to increase; and having increased, to become an adult; and having become an adult, to multiply; and having multiplied, to become strong; and having been strengthened, to be glorified; and being glorified, to see his Master; for God is he who is yet to be seen, and the vision of God produces incorruptibility, and ‘incorruptibility renders one close to God’ [Wis. 6:19].” (Hear. 4.38.3). quoted from Behr, 195-96.
Through the rhythm of God’s economy, human beings become conformed to God’s image.
Here Behr continues, “Such are the rhythm and movement of human life, which recapitulates the movement of the economy.” (196)
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 13: The First Order of Emission Established by the Heretics Is Indefensible

These activities can be spoken of in men and women, since men and women are composite in nature, consisting of body and soul.10 But whoever asserts that Thought is emitted from God, and Mind from Thought, and from these Word, are in the first place to be convicted of applying these emissions improperly. Second, although they are ignorant of [the nature of] God, they describe men’s and women’s actions and passions and intentions of the mind. They apply to the Father of all things, who, they assert, is unknown to all, the actions that occur in men and women that lead to the spoken word.11 They deny that he made the world lest he be considered small, but they ascribe human actions and passions to him! Now, if they had known the Scriptures and had been taught by the Truth, they would indeed have known that God is not like men and women,12 and that his thoughts are not like the thoughts of men and women.13 For the Father of all things is far removed from the actions and passions that men and women experience. He is simple and not composite; with all members of similar nature, being entirely similar and equal to himself. He is all Mind, all Spirit, all Understanding, all Thought, all Word, all Hearing, all Eye, all Light, and the whole Source of all blessings. That is how devout people can speak properly of God.14

Here is Irenaeus on divine simplicity. John Behr says, “Although ‘simple’ (cf. haer. 2.13.3, 28.5), God has worked out human salvation through this economy in a manifold fashion.” (191)
There is a interesting translation by Behr that economy (oikonomos) is ‘dispensing’; and that the Word is the ‘dispenser’ of the paternal grace.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 11: Proof from John’s Gospel that God Is One. There Are Only Four Gospels

For since the Father is invisible, the Son who is in His bosom declares Him to all. On this account, those to whom the Son has revealed Him, know Him; in turn, the Father, through the Son, gives knowledge of His Son to those who love Him.

For being in the same nature as the Father, the Son reveals the Father perfectly. This idea is however only implied here.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 11: Proof from John’s Gospel that God Is One. There Are Only Four Gospels

through His Son in these last times—the incomprehensible through the comprehensible, and the invisible through the visible, since He does not exist outside of the Father, but in His bosom.

Here, Irenaeus shows that the Christ is the revelation of the Father, for he has been in his bosom, for being in the same nature.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 25: Investigations about God Must Be Rational and Humble

If, however, anyone should not find the reason for all things about which he inquired, let him remember that man is infinitely inferior to God, and that man has received grace only in part and is not yet equal or like to the Creator; and, unlike God, he cannot experience and know all things. On the contrary, to the degree that he who today was made and began to exist as creature is inferior to him who was not made and who is always the same, to that degree he is inferior to him who made him, in knowledge and for investigating the reasons of all things. For you, O man, are not increate, nor did you always exist along with God, as his own Word did; but because of his preeminent goodness you now begin to exist as a creature and gradually learn from the Word the economies of God who made you.6

Here Irenaeus points out that man is imperfect now and grow into perfection of God.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 10: Witness from Luke and Mark

For the prophets did not announce different gods, but one and the same God under various expressions and by many titles. For, as we have shown in the preceding book, the Father is abundant and rich.38 This we shall show, too, from the prophets in the course of our treatise.

So in this place, as Irenaeus continues to show that Scripture consistently show that it is one God and not many divided gods as the Gnostics makes him to be assigning different identity to different activities of God, Irenaeus is keep showing that it is one and the same God. The importance of this observation is that the one same God has many activities and many attributes although they are only one. So, he is one God “under various expressions and by many titles.” The significance of this is that our God is “abundant and rich.” Here diversity and multiplicity is connected to the idea of him being “abundant and rich.” So, God’s attributes are not simply one, but that they are diverse, but united as one. Cf. 2.25.3 where Irenaeus says that the created are infinitely inferior to the creator, therefore we cannot come to the full knowledge of him, and that he created us out of his goodness, and not as the bad god of Marcion. Our God is abundant and rich God and this is his glory (Isa. 55:7, Rom. 10:12).
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 10: Witness from Luke and Mark

He says plainly that the voice of the holy prophets is the beginning of the Gospel

Here Irenaeus says that the voice of the prophets is the beginning of the Gospel; so the gospel began from the Old Testament.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 10: Witness from Luke and Mark

Really, all things were present in a new manner when the Word arranged His coming in the flesh, so that He might make into God’s possession that human nature [hominem/ἄνθρωπον) which had gone astray from God

The goal of Christ’s incarnation in flesh was the possession of human nature, to bring it back unto himself into union with himself.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 10: Witness from Luke and Mark

that He might become the Son of Man, in order that man in turn might become a son of God

Deification
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 8: What Is Mammon? (Matthew 6:24)

For He Himself is uncreated, without beginning and without end, in need of no one, self-sufficient, bestowing existence on all the rest. But the things made by Him have a beginning; and all things that have a beginning are also liable to dissolution, and are subject to, and in need of, Him who made them.14

The divine simplicity idea is here. In the footnote it says:
A concept that will be of great importance later, in Irenaeus’s argument throughout AH 4.38–39. Irenaeus here establishes his fundamental anthropological doctrine of man’s dependence on God, arising from his distinction from Him. Only God is uncreated and unchanging. That which He creates is, by virtue of its being created, “liable to dissolution,” subject to change, and ever in requirement of God for sustained existence. Irenaeus’s claims, in 4.38, that humanity must have been created as “imperfect” (ἀτελειότης) stem from this notion: if “perfection” is the state of being at one’s telos or fulfilled end (as the Greek term suggests, without the negative moral implications of the English), then that which shall change and grow over time is yet to be at this telos and must therefore be described as a-teleiotēs, “imperfect.” In this lies the heart of Irenaeus’s dynamic vision of human creation into growth and development, by which vision he is so often characterized. See R. F. Brown, “On the Necessary Imperfection of Creation: Irenaeus’ Adversus haereses IV, 38,” Scottish Journal of Theology 28, no. 1 (1975): 17–25; G. Wingren, Man and the Incarnation: A Study in the Biblical Theology of Irenaeus, trans. R. Mackenzie (Edinburgh: Oliver & Boyd, 1959), throughout; and M. C. Steenberg, “Children in Paradise: Adam and Eve as ‘Infants’ in Irenaeus of Lyons,” Journal of Early Christian Studies 12, no. 1 (2004): 20–22.1
AH AH Adversus haereses
1 Irenaeus of Lyons, St. Irenaeus of Lyons: Against the Heresies, Book 3, ed. Irenaeus M. C. Steenberg, trans. Dominic J. Unger, vol. 64, Ancient Christian Writers (New York; Mahwah, NJ: The Newman Press, 2012).
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 17: The Emission of the Aeons Is Very Illogical, Involving Father and Mind in Ignorance

Certainly, the Father of all things is not some composite, ensouled being, apart from Mind, as we have demonstrated before; but Mind is the Father, and the Father is Mind. And so the Word who springs from him, and much more so, Mind, since it is the Word, must necessarily be perfect and without passion; likewise, the emissions that sprang from him, being of the same substance as he, are perfect and without passion and must always remain like him who emitted them.

In this arguments against the opponents’ theory of emissions and different natures found therein, Irenaeus argues that what comes out of the Father, namely the Son, must be of same nature as the Father, as in light from light.
St. Irenaeus of Lyons: Against the Heresies, Book 3 Chapter 6: Proof that in the Scriptures No One Else Is Called God and Lord but the Only True God and His Word

The Lord said to my Lord, sit at my right hand, until I make your enemies your footstool.3 This shows the Father speaking to the Son, who gave to Him the inheritance of the Gentiles and subjected to Him all enemies.4 Since, therefore, the Father is truly Lord, and the Son truly Lord, the Holy Spirit deservedly designated them by the title “Lord.

Irenaeus points out the both the Father and the Son is Lord, and that the Holy Spirit designate both as “Lord.” Here, Irenaeus clearly shows that the Scripture was produced by the Spirit.
St. Irenaeus of Lyons: Against the Heresies, Book 3 “One and the Same” Lord as God

It is this proclamation of the scriptural Christ that is at the heart of the book.

Christ is scriptural Christ, and he is the recapitulation of all scripture.
St. Irenaeus of Lyons: Against the Heresies, Book 3 The Faith Received and Transmitted: The Fourfold Gospel

In the same way, Irenaeus is keen to identify and stress the apostolic origins of each account of what he does not call “the four Gospels” (as we are wont to do today), but, rather, the “fourfold Gospel which is held together by the one Spirit” (3.11.8)—stressing its common and divinely united proclamation.

Important note here that the fourfold gospel is one and is held together by one Spirit.
St. Irenaeus of Lyons: Against the Heresies, Book 3 The Faith Received and Transmitted: The Fourfold Gospel

Thus, for Irenaeus, the oral origins of the Gospel are part and parcel of the common voice of the Church’s true witness—for the four gospel accounts do not emerge out of independent textual or historical traditions, but out of the same, common oral preaching that was the product of the apostolic experience of Christ. So it is that, with respect to the written volumes of the evangelists, “all these have handed down to us that there is one God, the Creator of heaven and earth … and one Christ, God’s Son” (3.1.2)—that is, they each proclaim that common foundation of the true faith that is Irenaeus’s focus in this book.

Irenaeus’ points out the apostolic faith is in one gospel, one message, one Christ, and one Father of all. Church’s voice is one, apostolic voice (of oral tradition) is one, the Gospel is one, and God is one.
St. Irenaeus of Lyons: Against the Heresies, Book 3 The Faith Received and Transmitted: The Fourfold Gospel

not only of the ancient Scriptures but also of the apostolic witnesses of the one Gospel; and second, the receptive, transmitting nature of the Church, which receives that one Gospel and, like a nurturing mother, distributes it to her children.

The gospel is one, the apostolic tradition is one.
St. Irenaeus of Lyons: Against the Heresies, Book 3 The Overarching Theme: One and the Same God

As he notes in the preface, the teachings of the Valentinians and other groups (whom he has considered in Books 1 and 2) are varied and contradictory; but the teaching of the apostles, the teaching of the Church, is singular and true.

Contrary to the heretic groups, the teachings of the apostles and the church is one and singular. This is a theme that Irenaeus repeats throughout.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

Now if anyone likes to pick a fight and contradict what we have stated and what the Apostle has said, namely, that we know only in part, and we prophesy only in part,42 and thinks that he has received not only partial knowledge but absolutely real knowledge of all things that exist—he is really another Valentinus, or Ptolemaeus, or Basilides, or any other of those who claim that they have searched out the depths43 of God.

Here Irenaeus is arguing that God is incomprehensible to us so that a perfect knowledge of God is impossible, of how things are. This is in line with the Cappadocian Fathers.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

If, then, anyone asks the reason why the Father, who has all things in common with the Son

The Son has all things in common with the Father.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

If, then, anyone should ask us, How was the Son emitted by the Father? we reply, No one understands this emission, or generation, or calling, or manifestation, whatever name one might call his ineffable generation.25

Here he says that Son’s generation from the Father is ineffable. In this section, Irenaeus continue to argue that there are so many things that we cannot know, or are not in the realm of our knowing.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

Since, however, God is all Mind and all Word, what he thinks he speaks, and what he speaks he thinks. For his thought is his Word, and what he speaks he thinks. For his thought is his Word, and his Word is his Mind; and the Mind that contains all things is the Father himself. Whoever, therefore, speaks of God’s Mind and gives to this Mind an emission of its own proclaims him [God] to be a composite being, as if God were one thing and Mind, his principal [emission] another.21 Again, [if anyone speaks] of the Word in the same manner, making it the third emission in line from Father, which means that he is ignorant of his [Father’s] greatness, he has separated the Word very far from God. The Prophet, indeed, said of him: Who shall declare his generation?22 But you who divine his origin from Father and apply to God’s Word the emission of the human word made with the tongue are with good reason exposed by your own selves as ignorant of both human and divine matters.

Simplicity. Irenaeus says that there is no compositeness in God; so that he is all mind and all word, and his mind equals his word exactly. By implication, there is perfect unity between the Father and the Son.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

But since God is all mind, all intelligence, all spirit who is active, all light, and always existing the same and unchangeable,20 things beneficial for us to know about God, as we also learn from the Scriptures, such activities and parts cannot properly belong to God. The tongue, being fleshy, is not able to keep up with the speed of the human mind, which is spiritual; hence our word is held back within and is not instantaneously uttered as it was conceived by the mind, but piecemeal, as the tongue can minister to it.

Simplicity. God is all mind, all intelligence, all spirit, all light, etc. He is actus purus. There is no potentiality. Xenophanes?
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

So if, according to the method stated, we leave some of the questions in God’s hands, we shall keep our faith, and we ourselves shall persevere without danger; and we will find that all the Scripture given us by God harmonizes, and the parables harmonize with the things that are expressly stated, and the plain statements explain the parables. Thus, through the many voices of the passages there will be heard among us one harmonious melody12 that hymns praises to God who made all things. If, for example, anyone should ask us what God did before he created the world, we reply that the answer to this is in God’s keeping. The Scriptures do teach us that this world was made complete13 by God when it began in time; but no Scripture reveals what God did before this. So the answer to this is in God’s keeping; and you should not desire to discover foolish, senseless,14 and blasphemous emissions, nor reject God himself who made all things, by thinking you have discovered the emission of matter.15

Harmony of Scripture
Here, Irenaeus says that Scripture is in perfect harmony, although there are things that we cannot simply know. He says, “Thus, through the many voices of the passages there will be heard among us one harmonious melody that hymns praises to God who made all things.” In this light, many things that become one in harmonious melody gives glory to God.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

We, however, precisely inasmuch as we are inferior to God’s Word and his Spirit, have need of a knowledge of his mysteries

In this section, Irenaeus says that there are ‘knowledge’ that is too wonderful for us (mysterious) that we can’t know. We even do not know everything about this creation, and even more so with the spiritual things. Therefore it is erroneous to say that we can know everything there is in heavenly realm.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 28: Perfect Knowledge Cannot Be Attained in the Present Life

If, however, we cannot find a solution for all things in the Scriptures, nevertheless let us not look for another God besides the one who exists. That is the greatest impiety. Such matters we must leave to God who created us, since we know very well that the Scriptures are perfect, inasmuch as they were given by God’s Word and Spirit.5

Here is Irenaeus’ view that Scripture is perfect, because triune God produced it.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 17: The Emission of the Aeons Is Very Illogical, Involving Father and Mind in Ignorance

To be sure, it is impossible to admit any longer that from such an emission some are with passion and some without passion. So if they claim that all are without passion, they demolish their own system.

St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 17: The Emission of the Aeons Is Very Illogical, Involving Father and Mind in Ignorance

And were they simple and of one form, and in every way equal and similar, just as air and light are emitted; or were they composite and of different form, dissimilar to their fellow members?

Here Irenaeus asks the heretics on the manner of emission, whether it was in composite nature or in simple nature. So in Adv. Haer. 2.17, Irenaeus talks about the manner of emination in simplicity.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 11: The Heretics Have Fallen into a Profundity of Error

They [heretics] do not believe that this God who is above all things made, just as he willed, the diversified and dissimilar things in his own realm through the Word, since as a wise Architect1 and a very great king he is the Maker of all things.

God who is simple made “the diversified and dissimilar things.” From his simplicity came diversity.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 5: Our World Was Not Formed by Other Beings in Father’s Realm

It is not proper to assert that God, who is above all things, since he is free and has self-determining power, is a slave of necessity, inasmuch as something might be according to a concession of his but independent of his counsel. For then they would make necessity greater and more powerful than God, since whatever is more powerful is also more ancient than all. For immediately in the very beginning he would have had to do away with the cause of necessity and not bind himself to necessity by allowing something beyond what is becoming to him. Really, it would have been far better and more consistent and more godlike if he had cut off such a beginning of necessity from the start, than later, as if repentant, attempt to root out such a large crop of necessities. And if Father of all things would be a slave of necessity and fall under fate, unwillingly tolerating the things that happen, without being able to do anything against necessity or fate, he would be just like the Homeric Jupiter, who of necessity says, “For I gave to you, as if willing, yet with unwilling soul.”10 According to this reasoning, therefore, their Profundity will be found to be a slave of necessity and fate.

God is not a slave of necessity. There is no contingency upon him.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 2: The World Was Made Not by Angels but by the Father through the Word

One God, the Father, who is above all and throughout all and in us all

Here is a Scripture verse that supports the simplicity of God. He is of himself, and that there is no higher being than himself of which he participates. He is all that he is of himself, so it says, “who is above all and throughout all and in us all.” God being above all means that he contains all things, but he himself is not contained. God being “above all” means that he is not contingent upon anything.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 2: The World Was Made Not by Angels but by the Father through the Word

It is proper to God’s preeminence not to be in need of other instruments for creating things to be made.

God did not need anything else outside of himself as instrumental in creating the universe, therefore, he does not need anything outside of himself to sustain the world, and he does not need anything outside of himself to do what he does. He is free being, and is not contingent on anything, but is of himself.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 2: The World Was Made Not by Angels but by the Father through the Word

On the contrary, he predetermined in himself all things in advance according to his nature, which to us is ineffable and inscrutable, and he made them as he willed, bestowing on all things their form10 and order, and the principle of their creation—giving to spiritual beings a spiritual and invisible substance; to supercelestial, a supercelestial;11 to Angels, an angelic; to animals, an animal; to swimming creatures, an aquatic; to land creatures, one fitted for land; that is, giving to all a suitable substance.12 But all beings that have been made he made through his indefatigable Word.

The course of this world must be from God himself, and not from something outside of himself, such as the will of man. If God is contingent upon the will of man, then God is not above all things, but is contained. God cannot be contained by anything, and for this reason, uninfluenced completely free will of man cannot exist by definition of God himself.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 2: The World Was Made Not by Angels but by the Father through the Word

God has no need of anything that exists7 since he created all things and made them by his Word.8 He did not need Angels as helpers to make the things that are made, nor did he need any Power much inferior to himself and ignorant of the Father

Here, Irenaeus says that God did not need any lower beings than himself to create the world (such as Angels as argued), because he created the world by his Word. So this shows the complete sufficiency of God in creation; he did not rely on anything outside of himself to create the world, and he did not need anything ad extra. It was on his own, dependent upon himself alone.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 2: The World Was Made Not by Angels but by the Father through the Word

Next, let them tell us whether these things were made among the things enclosed by him and in his own realm, or in a realm that belongs to others and is outside of himself.

Here Irenaeus is countering views that angels or some other beings created the world than God himself. This would show that God is less concerned about the world than them.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

And it would be necessary to acknowledge that each one of them be, as it were, enclosed and remaining in his own realm. However, none of all these would be God, for each one of them would be deficient since that one possesses only a very small portion in relation to all the rest. And so the name Omnipotent would be destroyed, and such an opinion would of necessity fall into impiety.

If there are so called many Gods as in Valentianism, God would not be omnipotent.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

And then, by the same line of reasoning by which they attempt to teach that there is some Fullness or God above the Creator of heaven and earth, one would have to set up a Fullness above the first, and another above that, and another sea of deity9 above the Profundity. The same thing would have to be set up on the sides. And so their opinion would go on indefinitely, and it would always be necessary to think up other Fullnesses and other Profundities; and one would never come to a stop, always seeking others besides those mentioned.

If God is not simple in his being, then there would be myriads of other gods beside him, as argued by Valentianism.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

And so, talk about what is contained and what contains would go on forever. For, if this third something would have a beginning in the things above it and an end in the things below it, it is entirely necessary that it be limited also on the sides, either beginning or ending at some other beings. And these in turn, and others above and below, would have a beginning in relation to some other beings; and this would go on forever, so that their speculation would never come to a stop in the one God; but on the pretext of seeking after more than exists, this speculation would fall away into what does not exist and would separate itself from God.

In this paragraph, Irenaeus is showing the foolishness of the idea that God is dependent upon something else for his being. If he were to depend upon something else, then that reality out of God must be greater than God himself, and if a higher being is argued as Valentinianism does, then, this argument would go on forever, and thus would be foolish. So, here Irenaeus is continuing his earlier point that God is not contained by anything else in his being and essence, so he is of himself absolutely although he contains all things. The argument is that there is some Fullness or God above the Creator.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

These remarks are likewise appropriate against the followers of Marcion, for his two Gods will be contained and limited by the immeasurable interval that separates the one from the other.

There cannot be anything outside of God that conditions or contains him.
Irenaeus uses the same argument against Marcionism who argued that there are two Gods. His argument here is that if there are two Gods, then these two Gods would be contained by the interval that separates the two, because the two Gods would necessarily conditioned by this separation. Irenaeus’ argument here is clearly conditioned by the principle of divine simplicity that he is the highest possible thing, unconditioned by anything else external to himself. There cannot be any principle that conditions him, here even by the ‘interval’ between the two Gods of Marcionism. There cannot be a division in him that conditions his being. So, necessarily, God is above all and he is only one. This is the idea of simplicity that Irenaeus uses against Valentinus and Marcion.
So here, the question can be answered: “How does Irenaeus appropriate the doctrine of divine simplicity?” He previously argued against Valentinianism that there cannot be anything that contain God, otherwise, he wouldn’t be fullness. Here he uses it against Marcionism that if there are two Gods, the ‘interval’ that separates the two Gods would condition or contain God. But since he is the highest being, this cannot stand.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

This third something will put bounds around and contain both,8 and this third something will be greater than the Fullness and what is outside of it, inasmuch as it will contain both within itself.

Here the opponents argued that there is some other being outside of Fullness, and this alone is erroneous, because by definition, there cannot be outside of Fullness. By this Irenaeus shows that God cannot be dependent upon anything for his existence for he is absolute being in himself and by himself. He is not caused by anything.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

For anyone who is the end of the things below him necessarily and absolutely circumscribes and surrounds the thing of which he is the end. Again, according to them, Father of all, whom they style their Fullness and who is the good God of Marcion, will be contained, enclosed by something else, and surrounded from the outside by some other Authority5 that must, of necessity, be greater, since what contains something must be greater than that which is contained. Moreover, what is greater is also more stable and more powerful; and what is greater and more stable and more powerful—that will be God.6

Irenaeus uses this against the Gnostic ideas of Valentinus that God cannot by lower or contained by any other being.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

He would have a beginning, a middle, and an end in relation to the things outside of him.

He is the beginning, the middle, and the end in relation to everything outside of him, therefore nothing can be outside of him, and all things are contained in him in temporal sense here. God cannot be contained or conditioned by time. Time is contained in God and God is above time, and time cannot be above God, since God contains all things and is not contained by anything. This paragraph as whole explains this. He absolutely circumscribes and surrounds things below him.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

Really, how would it be possible for another Fullness or Beginning or Power or another God to be above him, since God, the Fullness of all things, necessarily contains them all without limit and is not contained by anyone?3 Now if there is anything outside of him, then he is no longer the Fullness of all things, and he does not contain all things, because whatever they say is outside of him will be lacking to the Fullness or to the God who is above all things. But what is lacking or taken away from something is not the Fullness of all things.

By implication of being the fullness, there cannot be anything outside of God. He contains all things and is not contained by anything else. This is a simplicity idea. There is nothing outside of God. Human will (freedom of will) is not outside of God.
St. Irenaeus of Lyons: Against the Heresies, Book 2 Chapter 1: There Is but One God: It Cannot Be Otherwise

he alone contains all things

He alone contains all things and is not contained by anything.
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